Several modern applications require audio encoders featuring low data rate and lowest delays. In terms of delay, Adaptive Differential Pulse Code Modulation (ADPCM) encoders are advantageous compared to block-based codecs due to their instantaneous output and therefore preferred in time-critical applications. If the the audio signal transport is done block-wise anyways, as in Audio over IP (AoIP) scenarios, additional advantages can be expected from block-wise coding. In this study, a generalized subband ADPCM concept using vector quantization with multiple realizations and configurations is shown. Additionally, a way of optimizing the codec parameters is derived. The results show that for the cost of small algorithmic delays the data rate of ADPCM can be significantly reduced while obtaining a similar or slightly increased perceptual quality. The largest algorithmic delay of about 1 ms at 44.1 kHz is still smaller than the ones of well-known low-delay codecs.