This work addresses sound modeling using a combination of physical and signal models with a particular emphasis on the flute sound. For that purpose, analysis methods adapted to the nonstationary nature of sounds are developed. Further on parameters characterizing the sound from a perceptive and a physical point of view are extracted. The synthesis process is then designed to reproduce a perceptive effect and to simulate the physical behavior of the sound generating system. The correspondence between analysis and synthesis parameters is crucial and can be achieved using both mathematical and perceptive criteria. Real-time control of such models makes it possible to use specially designed interfaces mirroring already existing sound generators like traditional musical instruments.